Molecular Medicine

Interaction of glutamatergic system inhibition and aerobic exercise on anxiety-like behaviors in rats

Introduction: Exploratory behaviors in rodents are an indicator of anxiety behaviors. In the present study, the combined effect of aerobic exercise with different intensities and inhibition of the glutamate system on exploratory behavior in rats was investigated. Materials and Methods: In this experimental study, 80 male Wistar rats were randomly divided into 10 groups including control, diazep...

Novel Insights to Celiac Disease: A review article

Celiac disease is a chronic, systemic and autoimmune disorder of gastrointestinal track that involves approximately 1% of individuals of all ages throughout the world. The collaboration of environmental factor such as gluten proteins and genetic factors, notably HLA-DQ2 and/or HLA-DQ8 trigger the disease. Gluten-free diet is the simply and merely safe and proficient existing treatment. This art...

Evaluation of MicroRNA-99a and MicroRNA-205 Expression Levels in Bladder Cancer

Bladder cancer is the second most common cancer in the genitourinary tract, showing often recurrence and progresse into invasive states. Epigenetic changes, such as microRNA alteration are involved in bladder cancer tumorigenesis through a variety of signaling pathways. The epigenetic state depends on geographic and lifestyle conditions. The aim of this study was to investigate the expression l...

Precision medicine, technologies, and molecular diagnostics

Introduction: Genetics, cellular and molecular medicines are cutting-edge sciences and technologies that play an important role in improving human health and quality of life. In addition, medical and biological sciences have clearly shown that the onset of diseases differs from person to person due to their different genetic profiles and variations in molecular basis. Therefore, it is feasible ...

Molecular Detection of TTV DNA in Chronic Hepatitis Patients from A Hospital in Kerman, Iran

Correlational studies on insulin resistance and leptin gene polymorphisms in peritoneal dialysis patients

Objective(s):The aim of the study was to investigate the relationship between insulin resistance (IR) and leptin (LEP) gene polymorphisms in peritoneal dialysis (PD) patients. Materials and Methods: From July 1, 2011 to August 1, 2011, patients who received chronic PD were chosen and divided into three groups (DM, high HOMR-IR, and low HOMR-IR). Two PCR products of LEP were sequenced and aligne...